In December 2020, a new MVTR test is added by United States Pharmacopeia (USP) to determine the Moisture Vapour Transmission Rate (MVTR) of the single unit, a unit-dose container such as Blister. This new test method is added to General Chapter/671/Container performance testing in which usually MVTR test in blister with filled desiccant and this method is being used since 1970 now in the new method instead of the desiccant now water is being used.
A few of the benefits of the new water-filled test method include:
- The results are more reliable because test containers filled with water provide a constant vapor-pressure difference across test container walls, offering improvements in MVTR testing compared to desiccant-filled containers where the vapor pressure inside may neither start nor remain below 0% to 10% RH.
- Samples are easier to prepare because filling with water is easier than filling with desiccant.
- Samples last longer and can be reused.
Let us see now how Industry would acquire this new addition in testing.