The cartons shippers employ have a substantial impact on costs in their supply chains. Cartons impact transportation, corrugated material and void fill costs. These costs are particularly sensitive to carton design for pickandpack operations where orders and items are assigned to specific cartons selected from a &ldquocarton regime&rdquo. Transportation costs the most important cost component impacted by a carton regime is transportation cost. It&rsquos about ten times the costs of corrugated and void fill. The general objective is to design a carton regime that minimizes transportation cost.