Cap-Lock is a combination of cap adapter and label. The adapter is placed on top of the primary closure of the syringe and equalizes the diameter differences of the syringe body and cap. The label wraps around the syringe body and the cap adapter. Once the syringe is opened, the integrated perforation provides irreversible tamper evidence. Cap-Lock plus RFID has an additional label-integrated RFID chip embedded in the upper part of the label at the level of the cap. Because the chip largely sits outside the liquid-filled area it enables reliable long-range reading.
Company’s G7 Process Control Master Certification exemplifies its commitment to quality and consistency in commercial print and packaging.
Airnov to showcase HAT IN vials and desiccant packet product range at China Association of Clinical Laboratory Practice Expo
• HAT® IN vial provides protection for diagnostic and nutraceutical products • Automatable drop-in desiccant packets among range on display
• CACLP Expo to be held on March 28-30, 2021, at the Chongqing International Expo Centre
The variability in batch sizes and the corresponding impact on packaging line efficiencies is an accepted norm throughout the pharmaceutical industry. Lengthy changeover procedures coupled with small batch sizes have a negative impact on KPI’s designed to track and improve inventory, throughput times, OEE and costs.
Demand volatility is driven by numerous factors, and many businesses struggle with forecast accuracy which often results in the need to overstock and overproduce. Holding vast amounts of pre-printed blister lidding material in inventory is neither efficient nor cost-effective and leads to high levels of waste and a negative impact on profitability and the environment.
Many pharmaceutical companies are looking to digital technology
For batch sizes of 5000 blisters or less, solutions such as Hapa’s BlisterJet, the IMA POD or Mediseal’s LSC allow for blister packs to be produced as brite stock on the blister lines. This removes packaging complexity from the line and allows it to operate with significantly improved levels of operational effectiveness. With blister production decoupled from packaging, the process of customizing and supplying product quickly and efficiently is assured. The digital printing system prints the exact number of sealed blank blisters in line with the market demand and the benefits are felt right through the supply chain.
Speaking to Pharmaceutical Technology, Hapa sales and marketing director gives the example of a drug supplied to 40 different countries in three different strengths. This leads to the need for 120 different variants and thus 120 different locations in inventory. The result is logistical complexity, poor asset utilisation, delivery delays, waste and much more.
Using digital technology as part of a ‘postponement strategy’ means that SKU proliferation is far easier to manage – neutral blisters are the leanest form of pack. With the complexity removed from the blister line, the utilization of the assets improves significantly.
Companies can be more eco-friendly with late-stage customization
As well as reducing the number of production lines needed and simplifying the SKU process, late-stage customization drastically reduces the time it takes to get a product to market. The leaner production process leads to increased flexibility and the ability to produce multiple product variants without overcomplicating the production process, cutting down the time and energy it takes to deliver product to the pharmacy/patient.
Also, the positive ecological impact is significant. The process of producing aluminium lidding material is extremely energy intensive with a correspondingly high CO2 emission level. Waste therefore has a both a financial cost and an environmental cost. Late-stage customization eliminates the waste associate with pre-printed foil. Furthermore, the waste created by overproduction and expired product in the supply chain can also be eliminated.
Runners, repeaters and strangers
Still, that’s not to say it’s all bad news for traditional batch production and pre-printed foil. The key to understanding the best approach is directly connected to average batch sizes and coding requirements.
Use of pre-printed material is more cost effective when packaging high volumes of product ”runners”
Hapa’s range of inline printers can be used to print foils for medium volumes ”repeaters”
Postponement provides the perfect solutions to batches under 5000 ”strangers”
Hapa sales and marketing director says: “Hapa are in a unique position to offer different technologies that cover the complete spectrum of production requirements. Systems such as the Hapa Web 4.0 and BlisterJet can all be used for this purpose.
“With small batch volumes, pre-printed materials are creating a lot of set up waste, high inventory levels, handling and costs. For nano batches, late-stage customization is the best approach.”
Hapa is the leading supplier of inline printing systems for pharmaceutical packaging, with partners utilizing their technology across the globe. Since the founding of the organisation in 1933, more than 10,000 of its systems were installed worldwide.
At this stage, the health and safety of our people, clients, partners, and local communities are our utmost priority. FlexLink keeps operating while our associates are working safely, either from home or on site. We are pursuing our day to day activities and support our customers remotely.
Our supply chain is secured, we continue to ship spare parts, components, and equipment and do installations and commissionings where it is safe to do so. The current situation will not discourage us, but rather encourage a greater sense of responsibility to overcome these difficult times together.
An especially designed plastic - polyethylene terephthalate or PET is widely used for packaging water, medicines, beverages, edible oil, etc across the world because of its safety, utility and economic viability for the packaging of products of mass consumption. PET is a clear, strong, safe, lightweight and completely recyclable plastic belonging to the polyester family.
Recently, the principal bench of National Green Tribunal dismissed a litigation filed by Him, Jagriti Uttaranchal Welfare Society in 2014 stating that Indian government has already ensured guidelines for safe and regulated use of plastics for packaging and as the industry is adhering to global guidelines formulated under Pharmacopeia no further legislation changes are required.
The order comes after an expert committee set up by the Health Ministry in 2015, led by former biotech secretary Dr MK Bhan, submitted a report to the tribunal stating, “There is no conclusive evidence to suggest that use of PET or additive like antimony for pharmaceutical packaging may leach substances beyond limits that pose threat to human health.”
“This NGT order comes in at the right time to affirm that PET is safe. PET clearly is an inseparable packaging of several products,” says Dr Rao VSV Vadlamudi, Former President, Indian Pharmaceutical Association.
Sachin Sharma, Director, GEM Recycling states, “The safety of PET has been repeatedly demonstrated through extensive studies, regulatory approvals and scientific testing, as well as its widespread use and acceptance for more than three decades. The order must pave way for strengthening regulatory guidelines by prescribing specific methods for disposal of pharmaceutical packaging wastes.”
The new solution is available in plastic tube diameters ranging from 30-50mm, and in four substrate varieties: polyethylene and recycled tubes, each with or without EVOH barrier.
The reduction of material usage is most apparent in the tube’s wall thickness, which has been reduced from 0.5 mm to 0.35 mm without, Neopac says, sacrificing “exemplary” haptics. Low profile closures are already in the pipeline with the aim of achieving maximum weight reduction in plastic tubes.
Neopac estimates that, in its own packaging manufacturing operations, the new tubes will eliminate the need for as much as 4.6 tonnes of HDPE materials per one million tubes produced. This translates to an overall carbon footprint reduction of about 8.6 tons of CO2 per million tubes manufactured.
“Finding ways to reduce the overall amount of material is mandatory for packaging suppliers to move toward ambitious sustainability goals,” says Cornelia Schmid, head of marketing at Hoffmann Neopac.
“The challenge is always to boost a pack’s eco-friendliness without sacrificing product protection or aesthetics. The new lightweight tubes are viable solutions for brand owners in a number of industries, helping meet increasing consumer desires for comprehensive product sustainability.”
Constantia Flexibles has announces a new product called Perpetua, a sustainable high-barrier packaging solution for pharma products. It is the company’s first recyclable polymeric mono-material, has a wide range of uses in pharma packaging applications and is now available worldwide. Perpetua offers excellent product protection from oxygen, water vapor and light.
High protection levels against moisture, oxygen and heat are important for protecting active pharmaceutical ingredients (APIs), to provide the patient with an effective medication. Constantia Flexibles’ goal was to meet the very high barrier properties for pharma products, while implementing the best possible sustainability standards. The result is Perpetua, a recyclable product family, based on a unique line of full PP (Polypropylene) high barrier laminates. The flexible packaging solution is available in application-tailored versions. Being cyclos-HTP certified, its recyclability ranges from 90% to 96%, depending on the individual material specification, the company says.
The high barrier properties and lower environmental footprint do not limit the design possibilities of the packaging.
Pierre-Henri Bruchon, EVP Pharma Division Constantia Flexibles, comments, “Our mission is to constantly rethink packaging to make a meaningful contribution to our customers and the environment. Sustainability plays a decisive role in all our business activities. Therefore, the development of a more sustainable but at the same time high-barrier solution for pharma products like Perpetua was of high importance to us. It is the perfect packaging solution for pharma products.”
The innovative Syringe-Closure-Wrap marking solution features a label that wraps around the syringe barrel and the complete cap. When the user pulls off the upper part of the label, the integrated first-opening indication is triggered. Due to special security die cuts, the label is irreversibly destroyed and cannot be closed again unnoticed. After the label has been opened for the first time, an additional warning appears as a visible security element. For increased product and counterfeiting protection, overt, covert or digital authentication features can be integrated into the label.
High protection levels against moisture, oxygen and heat are important for protecting active pharmaceutical ingredients (APIs), to provide the patient with an effective medication. Constantia Flexibles’ goal was to meet the very high barrier properties for pharma products, while implementing the best possible sustainability standards. The result is Perpetua, a recyclable product family, based on a unique line of full PP (Polypropylene) high barrier laminates. The flexible packaging solution is available in application-tailored versions. Being cyclos-HTP* certified, its recyclability ranges from 90% to 96%, depending on the individual material specification.
The high barrier properties and lower environmental footprint do not limit the design possibilities of the packaging.
- INDUSTRY UPDATES
- OUR PRODUCTS
- Our Partners