Paracetamol Is Successfully Used Against Pain And Fever Approximately 55 Billion Times A Year And Therefore Ranks Among The Most Common Medicines Worldwide Dolipranereg Is A Key Player On The French Market Thus The Production Quantities Are Correspondingly Large Sanofiaventis One Of The Worldrsquos Leading Pharmaceutical Companies Relies On Oystar Huumlttlin When It Comes To Manufacturing For Example At The Production Site In Cologne Germany Paracetamol Effervescent Tablets And In Lisieux France Paracetamol Tablets Both Ldquodolipranerdquo Brand Are Manufactured On Plants Supplied By The Granulation Expertsnbspin Cologne The Oystar Huumlttlin Htgnbsp1800 And Hdnbsp600 Units Produced Granulates For A Total Of 359 Million Effervescent Tablets For The French Market In 2009 This Rate Of Production Is Made Possible Through The Installation Of A Fully Integrated Granulating Line No Manual Operations Of Any Kind Are Necessary Ndash From Dustfree Loading Via Big Bags To Filling The Respective Container The Htgnbsp1800 Highshear Mixer Granulator And The Hdnbsp600 Fluidized Bed System Are Equipped With Pneumatic Filling Mechanisms Including Integrated Weighing Pneumatic Empty Mechanisms As Well As Pneumatic Transfer Between The Mixer And Fluidized Bed Thus Providing For A Completely Closed Production Process The Complete Plant Has A Shockproof Design And Satisfies The Highest Safety Requirementsnbspin Lisieux On The Other Hand Sanofiaventis Had The Fully Automated Hdgcnbsp1200 Fluidized Bed System From Oystar Huumlttlin Installed With An Upstream Big Bag Unloading Station The Apparatus Carries Out Two Process Steps Spray Granulation And The Drying Process In A Single Product Container The Initial Output Makes The Production Of Granulates Possible For More Than 500 Million Paracetamol Tablets Per Year Just Like In Cologne An Efficient Cleaning Concept Is Provided To Prevent Crosscontamination Thus Each Of The Plants Is Automatically Cleaned And Dried Overnight Via The Wip System Ldquowashing In Placerdquo From The Loading Station To Discharge So That Products Can Be Manufactured On The Following Morning With The Highest Degree Of Purity
