Various experimental parameters were systematically optimized and good linearities were obtained within the range of 0.05‐1.00 μg/ml for DBB and DBHBA and 0.50‐10.00 μg/ml for DBP, with limits of detection (LOD) of 0.99 ng/ml (DBB), 16.34 ng/ml (DBP) and 1.64 ng/ml (DBHBA), respectively. Satisfactory recoveries that ranged from 96.0 % to 107.2 % were acquired and the relative standard deviation (RSD) was no more than 4.7 %. The results showed that the maximum daily usage of DBB, DBP and DBHBA were 9.859 ng, 163.445 ng and 16.399 ng, respectively, which were far below the corresponding PDE values according to the safety assessment, indicating that the migration of analytes did not bring any potential safety risk. The compatibility between the drug and the packaging materials was favorable.