Round nasal spray bottles with snap-on neck finish 20 mm Sterile, sterilized available. These spray bottles are available for nasal and other applications. These are snap on with 20mm neck. Available full range 10ml to 50ml.
Standard material: HDPE
• Full range from 10 ml to 50 ml
• Also suitable for crimp-on pumps
• Delivered ready-to-fill (sterile) or gamma sterilized
• Officially approved by Aptar Pharma, Nemera and Silgan
It is extremely important for the success of medical treatment that patients adhere exactly to the medication prescribed to them. Numerous studies prove that adherence to therapy pays off. But studies also show that many patients ignore their treatment plans – out of stubbornness, carelessness or excessive demands. This so-called non-adherence not only jeopardizes the success of treatment, but also causes immense costs for the health care systems.
Hoffmann Neopac, a global provider of high-quality packaging for a broad array of industries and applications, has introduced the market’s first fully recyclable polyethylene-based tubes with high-density polyethylene (HDPE) flip-top caps. A breakthrough in the worldwide push for packaging sustainability, the mono-material tube + cap combination overcomes a longstanding functionality hurdle for hinged caps, which were previously made predominantly from less recyclable polypropylene (PP) materials.
The new tube solutions are a packaging first: fully recyclable tube solutions whose body, shoulder and caps are composed of a single material family. Also available in screw-top formats, the new tubes are ideal for health & beauty, food and pharma packaging applications.
In existing recycling streams, mono-material plastic packaging is exceedingly more preferable than combination plastics, as its comparable simplicity is considered fully recyclable in mechanical recycling plants and therefore a key factor in moving toward a truly circular packaging landscape.
In addition to the new HDPE flip-top caps, Neopac also is launching a comprehensive portfolio of PE screw caps. Manufactured entirely in-house, the screw caps are available in diameters of 10-40mm.
“Achieved in collaboration with a long-time supplier, the new HDPE flip-top caps overcome the last hurdle to fully recyclable tube packaging – namely, the ability to form functional closures from the same material as the tube body and shoulder,” said Simon Böhlen, Development Engineer for Neopac. “Health & beauty, food and pharmaceuticals brands can now assure their increasingly sustainability-conscious customers that the packaging in which their products are housed has the lowest-possible environmental impact, as we move toward a fully circular packaging economy.”
The full PE Cap range is now commercially available for all Neopac’s PE, COEX, EcoDesign or Polyfoil Range. Starting November 2020, the recyclable fully mono-material PE Tubes with Flip-top cap will be available as stock solutions with the new printing service DigitAll360°.
Looking ahead, Neopac is currently in the development stages of next-generation, HDPE-optimized high-performance barrier tubes (Polyfoil® MMB) with superior decoration options. Available with PE screw-top caps, the forthcoming solutions already have received excellent ratings from Institute Cyclos-HTP, a packaging recyclability certification organization.
Aptar Pharma and Noble Partner with dne pharma, a European Leader in Addiction Medicine, on Ventizolve® Nasal Naloxone TreatmentNews:
Aptar Pharma, a global leader in drug delivery systems, services and active packaging solutions and Noble, an Aptar Pharma company, world leader in drug delivery training device programs, today announced their collaboration with dne pharma, a leader in addiction medicine in Northern Europe.
Using Aptar Pharma’s patented Unidose Liquid System, Ventizolve® is a ready-to-use rescue treatment that can quickly reverse the life-threatening effects of an opioid overdose. Noble’s Unidose trainer kit, which replicates Aptar’s Unidose device, will be used by dne pharma as part of a broad patient onboarding and awareness program for Ventizolve® in outreach and drug treatment centers across the Nordics – the first trainer kit of its kind for a naloxone nasal drug product launch.
According to The World Health Organization (WHO), opioids and opioid overdose account for more than 70% of the half a million drug-use related deaths that are reported annually worldwide. In their Opioid Task Force 2020 Progress Report, the American Medical Association (AMA) states that a “continuing increase in drug overdoses is fueling the evolution of a more dangerous and complicated epidemic”, and urges stakeholders to come together to work collaboratively on meaningful action to remove barriers and increase patient access to evidence-based care, both to save lives and help end the epidemic.
Dne pharma’s focus is on improving existing treatments within addiction therapy. Nina Måsvær, Marketing Manager at dne pharma explains, “With the growing opioid overdose epidemic, we were fortunate to collaborate with Professor Ola Dale at the Norwegian University of Science and Technology in Trondheim on the development of a nasal naloxone sprayer for pre-hospital and take-home use and were able to secure final use approval for Ventizolve® in 12 European countries in 2018.”
Nasally Administered Opioid Overdose Rescue Treatment
Aptar Pharma’s Unidose Liquid System is the drug delivery device used to administer Ventizolve® and is a ready-to-use, one-step nasal device designed to enable the delivery of a precise, single dose quickly, easily and reliably, and without the need for administration by a trained professional.
“With over 100 million devices sold worldwide, our patented Unidose Technology Platforms are approved by the U.S. FDA and European regulatory authorities for a wide range of treatments from chronic conditions such as migraine and vitamin B12 deficiency to life-saving drugs that counter an opioid overdose,” commented Isabelle Menard, Director of Strategy and Business Integration at Aptar Pharma.
Noble is providing the training and onboarding component with its Unidose training device that replicates the form and function of Aptar Pharma’s Unidose drug delivery device. The Unidose training device features a novel twist reset function, making it easier for users and caregivers to practice administering a dose quickly and effectively so that they are ready when confronted with an emergency situation.
“We’re honored to provide the training support for this important initiative to combat the growing opioid overdose epidemic,” added Joe Masci, Noble’s Executive Director of Business Development. “The levels of anxiety that come with using a drug delivery device can be high under normal circumstances, let alone under stress and using a product you are not familiar with. When faced with an emergency situation, users need to have the confidence to come to someone’s aid.”
Drug Repurposing to Nasal Drug Delivery
Dne pharma is among a new generation of industry disruptors who are making their mark by repurposing existing therapies for nasal drug delivery, with benefits such as better patient convenience, greater personal empowerment, improved user compliance, and in some cases, overcoming objections to more invasive delivery routes. More importantly, in the case of a rescue treatment, the recipient does not need a healthcare professional (HCP) to administer the drug, which could be life-critical in an emergency situation where, for example, the patient is unconscious.
“Aptar Pharma’s expertise in drug repurposing using nasal delivery solutions, combined with Noble’s innovative training and onboarding platform, make them the perfect partners to support us in bringing this life-saving drug product to market,” concluded Nina Måsvær, dne pharma.
Innovative dispensing design with premium barrier protection & chemical compatibility, small-dose delivery accuracy in a sustainable way by reducing over-packaging. Perfect for dogs and cats anti-parasite, otitis and ophthalmology treatments.
What is Migration?
Migration is the transfer of chemical compounds from plastic packaging materials into food products.
These chemical compounds are usually present in inks and adhesives that travel through the primary packaging material to contaminate the contents. This can be extremely dangerous when the contents are either food or medicines.
Earlier, migration testing was only performed on containers, closures and other packaging components, excluding labels.
Cap-Lock is a combination of cap adapter and label. The adapter is placed on top of the primary closure of the syringe and equalizes the diameter differences of the syringe body and cap. The label wraps around the syringe body and the cap adapter. Once the syringe is opened, the integrated perforation provides irreversible tamper evidence. Cap-Lock plus RFID has an additional label-integrated RFID chip embedded in the upper part of the label at the level of the cap. Because the chip largely sits outside the liquid-filled area it enables reliable long-range reading.
Company’s G7 Process Control Master Certification exemplifies its commitment to quality and consistency in commercial print and packaging.
Airnov to showcase HAT IN vials and desiccant packet product range at China Association of Clinical Laboratory Practice Expo
• HAT® IN vial provides protection for diagnostic and nutraceutical products • Automatable drop-in desiccant packets among range on display
• CACLP Expo to be held on March 28-30, 2021, at the Chongqing International Expo Centre
The variability in batch sizes and the corresponding impact on packaging line efficiencies is an accepted norm throughout the pharmaceutical industry. Lengthy changeover procedures coupled with small batch sizes have a negative impact on KPI’s designed to track and improve inventory, throughput times, OEE and costs.
Demand volatility is driven by numerous factors, and many businesses struggle with forecast accuracy which often results in the need to overstock and overproduce. Holding vast amounts of pre-printed blister lidding material in inventory is neither efficient nor cost-effective and leads to high levels of waste and a negative impact on profitability and the environment.
Many pharmaceutical companies are looking to digital technology
For batch sizes of 5000 blisters or less, solutions such as Hapa’s BlisterJet, the IMA POD or Mediseal’s LSC allow for blister packs to be produced as brite stock on the blister lines. This removes packaging complexity from the line and allows it to operate with significantly improved levels of operational effectiveness. With blister production decoupled from packaging, the process of customizing and supplying product quickly and efficiently is assured. The digital printing system prints the exact number of sealed blank blisters in line with the market demand and the benefits are felt right through the supply chain.
Speaking to Pharmaceutical Technology, Hapa sales and marketing director gives the example of a drug supplied to 40 different countries in three different strengths. This leads to the need for 120 different variants and thus 120 different locations in inventory. The result is logistical complexity, poor asset utilisation, delivery delays, waste and much more.
Using digital technology as part of a ‘postponement strategy’ means that SKU proliferation is far easier to manage – neutral blisters are the leanest form of pack. With the complexity removed from the blister line, the utilization of the assets improves significantly.
Companies can be more eco-friendly with late-stage customization
As well as reducing the number of production lines needed and simplifying the SKU process, late-stage customization drastically reduces the time it takes to get a product to market. The leaner production process leads to increased flexibility and the ability to produce multiple product variants without overcomplicating the production process, cutting down the time and energy it takes to deliver product to the pharmacy/patient.
Also, the positive ecological impact is significant. The process of producing aluminium lidding material is extremely energy intensive with a correspondingly high CO2 emission level. Waste therefore has a both a financial cost and an environmental cost. Late-stage customization eliminates the waste associate with pre-printed foil. Furthermore, the waste created by overproduction and expired product in the supply chain can also be eliminated.
Runners, repeaters and strangers
Still, that’s not to say it’s all bad news for traditional batch production and pre-printed foil. The key to understanding the best approach is directly connected to average batch sizes and coding requirements.
Use of pre-printed material is more cost effective when packaging high volumes of product ”runners”
Hapa’s range of inline printers can be used to print foils for medium volumes ”repeaters”
Postponement provides the perfect solutions to batches under 5000 ”strangers”
Hapa sales and marketing director says: “Hapa are in a unique position to offer different technologies that cover the complete spectrum of production requirements. Systems such as the Hapa Web 4.0 and BlisterJet can all be used for this purpose.
“With small batch volumes, pre-printed materials are creating a lot of set up waste, high inventory levels, handling and costs. For nano batches, late-stage customization is the best approach.”
Hapa is the leading supplier of inline printing systems for pharmaceutical packaging, with partners utilizing their technology across the globe. Since the founding of the organisation in 1933, more than 10,000 of its systems were installed worldwide.
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