Packaging Equipment for Pharma applications

Mallya

Turn your pen injector into a smart device!

Mallya, the smart cap for pen injectors.
Mallya automatically captures injection data (dose, date and time) and sends the information in real time to a companion software thanks to Bluetooth technology. Mallya is the only device available in its category to be labeled CE medical device, class IIb.

FEATURES

• Removable and reusable for 2 years
• Compatible with all disposable pen injectors
• Seamless for patients: same usage, same dialing, same injection process
• Automatic collection of selected doses with very high accuracy
• Real time data transfer thanks to Bluetooth technology
• Track records of each injection: dose delivered, insulin type, time and date
• Audio and visual signals to guide patients during injection process
• Highly customizable: color, additional functionalities available
• Effortless innovative pairing system with smartphone
• High interoperability with existing platforms and digital solutions

AWARDS

Pharmapack Award 2016
Frost & Sullivan 2016
CPhI Award 2017

BIOCORP Mallya from BIOCORP on Vimeo.

Injay -

Injay, offering connectivity to conventional PFS

Injay: Trace it easy!
Injay collects essential information such as injection completed, time and date, type of drug, batch number and expiration date. Information is sent via NFC technology to an app on mobile, tablet or PC.

FEATURES

• Ergonomic handling and intuitive use of the device
• Seamless for patients: same usage, same injection process
• Adaptable to any PFS size (0.5, 1, 2.25 ml…) or material (glass, plastic, COP…)
• Able to trace any injection completion status
• Customizable information data up to 150 characters
• Standard or customizable backstop: shape and color
Product under development, not yet available on the market.

Inspair -

Thanks to Inspair, breathe effectively!

Inspair, smart cap to monitor inhalers’ use and improve quality of delivery.
Inspair automatically captures each actuation of the inhaler and assesses the usage of the device: right actuation time, optimal hand-breath coordination, proper respiratory air flow. The data are transferred in real time to a companion software thanks to Bluetooth technology.

FEATURES

• Removable and reusable for 2 years
•Compatible with pMDIs and adaptable for several type of inhalers or respiratory devices
•Captures each actuation of the inhaler together with time and date
•Assess proper use of the inhaler: actuation time, hand-breath coordination, indicator of respiratory air flow
•Real time data transfer to a companion software thanks to Bluetooth technology
•Treatment history and quality of delivery assessment
•Audio and visual signals to support the patient during inhalation process
•Potential applications : remote clinical trials monitoring, training device for onboarding period, commercial launch

AWARDS

E-health award 2017
Product under development, not yet available on the market.

Injection moulding

Moulding under Clean room ISO 7 (300 m²)
Moulding under Clean room ISO 8 (120 m²)
Design & production of plastic MD by injection moulding
Injection presses from 50 to 150 T
Uninterrupted production 24/24 – 7/7

Assembly / Packaging

Assembly

Multi-components assembly machine (ISO 7)
Printing machines (tube, blister, pipette …)
Ultrasonic welding
Contract manufacturing for plastic components (droppers, cannulas, backstop, closures, pipettes, tubes, collutary …)
Devices assembly including electro

Packaging

Soft & rigid blistering machines (ISO 8)
Single & multiple packs
Sterile products
Certificates of analysis

Dosing/Filling

Biocorp offers its tube or vial dosing-filling services for medical device formulations as well.
• For medical devices:
• Vials 15 à 30 ml
• Tubes 6 à 50 ml

On Demand Manufacturing

Our expertise in products development and our robust R&D process lead us to develop tailored solutions for our customers and packaging partners.
BIOCORP offers specific developments, either based on existing developed technology platforms or URS clients. This approach applies to simple components, reconstitution systems or drug delivery system.
BIOCORP accompanies the project and its client throughout the process of development and industrialization.

Pharma Vacumm Sealer With Gas Flush MSB11MVI ID Pharma

• Compliant with 21 CFR regulations Part 11
• Sealing bars closed/opened manually
• Recording of the various sealing programmes
• Sealing parameters adjusted on touch screen
• The controlled temperature of the sealing bars helps to reduce their wear
• Hygienic design
• Made of 304 stainless steel
• Easy to use

Plastic Bag Sealer

• Sealing parameters adjusted on touch screen
• Protects the card insert (no staples)
• Tamper-proof packaging
• Easy to clean and disassemble

Pneumatic Sealer - MSB11P ID

• Impulse Driver for uniform seal quality
• Ethernet connection for data recording and restitution
• Sealing bars closed/opened pneumatically
• Low pressure closing for operator safety
• Sealing parameters adjusted and recorded on touch screen
• Recording of the various sealing programmes
• Hygienic design
• Stainless steel throughout

Newguard

Your passive safety system.

Newguard, the new generation safety device. Newguard is the first device combining safety and needle protection functions. Compatible with various sizes of pre-filled syringes, Newguard adapts to the filling, sterilization and packaging process without requiring any change from the manufacturer. Easy to use, Newguard ensures safety and comfort during and after the injection.

Assets:

• Open source solution for pharma companies
• Compatible with all glass & elastomer suppliers
• Standardization for 0,5 ml & 1 ml PFS
• TCO reduction and secondary packaging optimization (size and costs)
• Available in thermoplastic elastomer and most common rubber formulation
• Easy integration to existing processes (filling and packaging lines)
• High level of acceptance by end users (patients, nurses)
Product under development, not yet available on the market.

Closure systems -

Newseal, Easy-off and Carpseal.

Substitute aluminum with plastic could be a solution to tackle several industrial issues. Aluminum crimping is currently processed in non sterile environment, with risks of contamination for the final product. The handling of aluminum creates risks of injuries for healthcare professionals.

Assets:

• Limit risks of contamination due to crimping operation
• Guarantee product sterility: vial /cartridge sealed in sterile area
• Improve user security: reduce risks of accidental injuries
• Ease industrial process: sealing system by simple “snap-on” pressure

Biopass -

Biopass, innovative reconstitution system.

A reconstitution set with an integrated needle ready for injection.

Assets:

• Easy fixation to 13 mm & 20 mm vials
• Fits luer-lock syringes
• Diluent transfer
• Needle ready to inject

Biocorp_biopass from BIOCORP on Vimeo.

Sween

Easy to use needle inserter

Sween, the needle inserter that helps you in your daily injections
Sween assists the patient in inserting the needle into the skin to the correct depth prior to injection and reduces the fear related to injection process.
This device provides real assistance in the administration of medication as well as being easy to hold and making no change to the pen’s use itself.
This device helps improve treatment and increase patients’ confidence in the management of their disease.

Sween can be used in different therapeutic areas such as:

• Diabetes: especially new diabetes patients who start insulin therapy,
• Growth hormone: children requiring growth hormone treatment
• Fertility disorders: women involved in a medically assisted procreation process
• Osteoporosis: men and women who need to take injectable medication for osteoporosis

Sween is consequently compatible with different disposable and reusable injection pens, including:

• Novo Nordisk: FlexPen, FlexTouch, Ozempic, Novopens
• Eli Lilly: Kwikpen and Humapen Savvio, FlexPro (5, 10 and 15 mg excluded), Nordiflex 5 and 10 mg and Humatropen 6,12 and 24 mg • Eli Lilly: Kwikpen and Humapen Savvio, FlexPro (5, 10 and 15 mg excluded), Nordiflex 5 and 10 mg and Humatropen 6,12 and 24 mg
• Pfizer: Goquick Genotonorm 5 and 12 mg
• Merck: Aluetta 6, 12 and 20 mg, Gonal-F, l’Ovitrelle, Pergoveris
• Sandoz: Omnitrope Pen 5, 10 and 15 mg
• Ferring: Rekovelle
• Radius Health: Tymlos

Using Sween, the act of self-injection of medicines by patients using injection pens is easier, more serene and safer.

Sween is being developed as a class I medical device, under Medical Device Regulation 2017/745.

Bag With Side Gussets Bags

Application
• Designed for high vacuum packing, irrespective of the type of product
• Vacuum created in stages (for the most volatile powders and hot products)
• One or several packages handled per cycle
• Precise management of vacuum and gas flush levels
• Recording of different recipes
• Automation possible for high production rates
• Touch screen for easy settings
• 10 mm wide seal
• Made of 304 stainless steel
• Hygienic design
• Easy to use

Advantages
• The side gussets open out to form a flat bottom that fits perfectly into the dimensions of the container (custom designed to your needs)
• This design offers both rigidity and stability when filling the bags
• When used with a lining, they have even greater mechanical strength (a UN certificate can be provided)
• They can be directly packed onto pallets without having to be boxed first
• Thanks to the corner seals of the gussets, nothing can remain trapped in the bottom
• They offer good protection while enabling vacuum or gas flush packing according to the material

Bags With Side Gussets (4SL)

Applications
• Food processing products flavourings additives, seeds base products
• Pharmaceutical products active principles vitamins capsules, injection blow moulded plastic parts, caps
• Chemicals colourants phytosanitary products metal powder polyamide granules, special cements

Advantages
• The side gussets open out to fit perfectly into the dimensions of the container (custom designed to your needs)
• This format is ideal for packaging large volumes of materials
• It offers both rigidity and stability when filling the bags
• They can be packed directly onto pallets without having to be boxed first
• Thanks to the corner seals of the gussets, nothing can remain trapped in the bottom
• They offer good protection while enabling vacuum or gas flush packing according to the material

Big Bag And Octabin Liners

Applications
• Food products: seeds (SAFET’HY ®process), oxygen sensitive products
• Pharmaceutical products: active principles, vitamins
• Chemicals: metal powders, polyamide or preformed granules, special cements

Advantages
• Ultra high protection of bulk products against oxidation and moisture
• Spouts for easy filling and discharging
• Suitable for vacuum packing (increased shelf life, quality assurance, long distance transportation)
• Vacuum packing eliminates the need to use additives (antioxidants or insecticides)
• Aluminium or EVOH barrier film
• Volume from 80 L to 2 000 L

Flat Pouches and Bags

Applications
• Food processing products flavourings additives, seeds base products
• Pharmaceutical products active principles vitamins capsules, injection blow moulded plastic parts, caps
• Chemicals colourants phytosanitary products metal powder polyamide granules, special cements

Advantages
• We offer custom sizes as well as a small format 130 x 200 mm and a large format 1000 x 1400 mm
• Easy to seal
• The pouch may be customized with rounded corners, tear notch or zip closure
• They can be easily moulded to fit a box using the automatic former manufactured by Bernhardt

Pouches With Flat Bottomed Gusset

Applications
• Food processing products flavourings additives, seeds base products
• Pharmaceutical products active principles vitamins
• capsules, injection blow moulded plastic parts, caps
• Chemicals colourants phytosanitary products metal powder polyamide granules, special cements

Advantages
• When the gusset is opened out at the bottom, it can fit perfectly to the dimensions of the container ( drum or box)
• Dimensions customized to your needs
• Protection of your products by vacuum packing or gas flushing
• Nothing can remain trapped in the bottom thanks to the corner seals of the bottom gusset

Sachets With Bottom Gusset

Applications
• Food products flavourings products in sauces, spreadable foodstuffs seeds special malts
• Pharmaceutical products active principles vitamins Capsules
• Chemicals colourants phytosanitary products

Advantages
• An attractive packaging solution, they stand up on their own thanks to the rounded gusset in the bottom
• They offer good protection while enabling vacuum or gas flush packing according to the material
• Filling can be done hot or cold
• Can be used for pasteurizing or sterilizing products
• Aluminium EVOH or Alox barrier
• Much more compact than a rigid container of equivalent volume

TTAB* Bag In Boxes (*Tuck Top Auto Bottom)

Applications
• Food processing products : flavourings , additives, seeds , base products
• Pharmaceutical products : active principles, vitamins, capsules, injection blow moulded plastic parts, caps
• Chemicals : colourants , phytosanitary products , metal powder , polyamide granules, special cements

Advantages
• Good protection of products while enabling vacuum or gas flush packing according to the material
• The sealed bag is tamper proof once filled
• Ensures total safety during handling and transportation
• Suitable for the transport of dangerous materials
• Flat pack for storage space saving
• Easy to palletize once full
• Supplied in packs of 50 60 and 80 L boxes) to 160 20 L boxes) 4 models 20 40 60 and 80 litres

Bulk-Liners

Applications
• Food products aseptic filling environment egg based products cream fruit juices soups syrups coulis, jams
• Pharmaceutical products storage of intermediate products before packaging into smaller batches
• Chemicals mineral oils
• Cosmetics essential oils detergents

Advantages
• The product is protected by the liner which collapses as the product is dispensed
• It is not therefore necessary to top it up with inert gas
• Less product loss (as little as 1 in some cases)
• No risk of product contamination
• Increased production throughput
• Space saving when empty (for storage before filling and return transport)

Drum Liners For 10 to 30L Drums

Applications
• Beers and sodas
• Sensitive products used over a period of time liquid flavourings special adhesives

Advantages
• The liners can be used with the reusable drums supplied by our partner Ecofass
• The liner collapses into itself as the liquid is drawn from the drum
• This way, Bernhardt’s liners protect your products throughout their period of use
• No need to clean the inside of the drum
• No risk of product contamination
• Reduced product loss only 1 residual product

Pillow Pouches

Applications
• Food products: cold or hot fill, pasteurized or sterilized egg based products, cream, soup, fruit
• Coulis jams
• Pharmaceutical products: products for lyophilization
• Chemicals: colourants, paints, solvents
• Cosmetics: essential oils, detergents, hygiene products

Advantages
• Ideal for products used over a period of time
• Easy to empty with a continuous and precise flow preventing any air intake
• High barrier film version for extra sensitive products
• Suitable for hot fill, self-pasteurization and sterilization
• Custom dimensions for special applications (lyophilization sterilization)

Pouches With Bottom Gusset

Applications
• Food products: cold or hot fill, pasteurized or sterilized egg based products , cream , soup , fruit coulis, jams
• Pharmaceutical products: ultra-pure water.
• Chemicals: colourants, paints, solvents
• Cosmetics: essential oils, detergents, hygiene products

Advantages
• The bottom gusset makes this a highly stable form of packaging
• The outer film can be printed with promotional or informative content
• High barrier film version for extra sensitive products
• Suitable for hot fill, self-pasteurization and sterilization
• Compact, they generate less waste after use

Special Flexible Pouches

Applications
• High barrier pouches suitable for peristaltic pumps.

Advantages
• Pouch integrated into a backpack and discharged by a dosing gun (to replace use of compressors)
• Pouch with holes, enabling it to be suspended, and handles for easy carrying
• New film structure developed to withstand a drop test from a height of 1 80 m
• Pouch manufacturing method modified for increased mechanical strength and to attain UN certification for use with powders
• Patented system for extracting liquids from flexible packaging inside a pressurized container

Standup Pouches With Side Gussets

Applications

• Food products: cold or hot fill, pasteurized or sterilized egg based products , cream , soup , fruit coulis, jams
• Pharmaceutical products: ultra-pure water.
• Chemicals : colourants , paints , solvents
• Cosmetics : essential oils , detergents , hygiene products
Advantages

• They offer excellent strength and can contain up to 5 L
• Easy to carry with handles at top and bottom (bottom only for pouches with screw cap at top)
• They are easy to empty with a continuous and precise flow preventing any air intake
• Compared to rigid containers, they occupy 90 less space prior to filling
• The outer film can be printed with promotional or informative content
• High barrier film version for extra sensitive products
• Suitable for hot fill, self-pasteurization and sterilization